This question asks students to provide a Punnett square and to compare, children predicted, with the actual children shown in the pedigree based on a given scenario about sickle cell disease. This is an extended response test item used in a past Ohio Graduation Test assessment (for more information, see IMS: Assessments). From this test item, a visitor may view the passages and stimuli, and information regarding general student performance on this item. The Ohio Department of Education’s IMS website allows visitors to search for test items and build a printable database of questions by choosing the "Add to Your Backpack" function. ODE Reference Information: 2005-Grade 10 Science, Annotated Item 12. (author/ts)